American actress, Melissa McCarthy, became famous when she starred in the television series, Gilmore Girls, which ran from 2000 to 2007. The sitcom, Mike & Molly, which ran from 2010 to 2016, further brought her accolades. She has also been part of films like This is 40, Identity Thief, The Heat, The Boss, Bridesmaids, Tammy, Spy and Can You Ever Forgive Me.
Kate McKinnon is a popular American actress and comedian known for her work in sketch comedy series, such as Saturday Night Live and The Big Gay Sketch Show. She is also famous for co-creating a web-series called Notary Publix and an audio series titled Heads Will Roll. An openly gay actress, McKinnon serves as an inspiration to the LGBT community.
One of the most popular actresses of the 1960s, Lucille Ball created the sitcom, I Love Lucy, in 1951. In 1962, she started managing the Desilu Productions, becoming the first woman to run a major TV studio. The recipient of two stars on the Hollywood Walk of Fame, Lucille became an inductee of the Television Hall of Fame in 1984.
An actress, writer, singer, and comedian, Lisa Kudrow gained international fame for portraying the iconic character Phoebe Buffay in one of the most popular American sitcoms of all time - Friends. She is also one of the highest-grossing film actresses as her movies have grossed more than $2 billion worldwide.
The co-founder of Upright Citizens Brigade, an improvisational-comedy troupe, Amy Poehler went on to utilize her comedic skills to establish herself as a prominent Hollywood personality. Over the years, she has played a crucial role in enhancing the popularity of American television, for which she was honored with a star on the Hollywood Walk of Fame.
6 Tina Fey
Carol Burnett inspired a lot of women and set off a chain reaction by hosting her groundbreaking show The Carol Burnett Show. Regarded as one of USA's most cherished entertainers, Carol continues to enhance the lives of millions, for which she was honored with the Presidential Medal of Freedom. She has also won the Mark Twain Prize for American Humor.
African-American comedian and actress, Tiffany Haddish, gained fame with the ensemble comedy film Girls Trip. Earlier, a difficult childhood turned her towards comedy. After appearing in a comedy competition, sketch comedies and numerous minor roles in films and television, she made the heads turn with her brilliant performance in television series, Real Husbands of Hollywood, If Loving You Is Wrong and The Carmichael Show.
From hosting her comedy show The Sarah Silverman Program, to winning an Emmy and writing a best-selling autobiography, Sarah Silverman has done it all. The NYU drop-out started off as a writer for SNL. She has been an ardent Democratic supporter and often discusses controversial topics on her show.
Mary Steenburgen is an American actress and musician. Also an active humanitarian, Steenburgen has been involved with several groups that work towards the welfare of people and the environment. In 2005, she inspired students at the Clinton School of Public Service with her lecture on students' role in public service.
11 Kathryn Hahn
12 Mindy Kaling
Actress, comedian, and writer Mindy Kaling first gained international fame with her work in the NBC sitcom, The Office, for which she was nominated for several Primetime Emmy Awards. She earned a bachelor's degree in playwriting before beginning her career. As the child of immigrants from India, she is one of the few Indian-American women active in the industry.
13 Lily Tomlin
Lily Tomlin is an American comedian, actress, singer, and writer. Tomlin has earned several award nominations for her performance in films and TV series, such as Nashville and Grace and Frankie. An openly lesbian actress, Lily Tomlin serves as an inspiration to the LGBTQ community.
14 Ellie Kemper
16 Joan Cusack
Actress and comedian, Joan Cusack was born to a family with a legacy in acting. Talented and ambitious from a young age, she started by playing small roles in films before gaining popularity with her performance in the comedy sketch show Saturday Night Live. She has also acted in numerous critically acclaimed films.
Primetime Emmy-winning Canadian-American actor and comedian Catherine O'Hara soared to fame with the sketch-comedy show SCTV. She is known for her frequent appearances in the films of Tim Burton and Christopher Guest. She is the sister of singer Mary Margaret O'Hara and is herself a fairly decent singer.
Accomplished American comedian, actress, singer and Broadway star, Whoopi Goldberg is amongst the select few who have won all the four awards—Emmy, Grammy, Oscar and Tony. Moreover, she is also a political activist, author and talk show host. Her notable work include films Ghost, Sister Act and The Color Purple; Broadway show Thoroughly Modern Millie and talk show The View.
Fran Drescher is an American actress and comedian. Characterized by her thick New York accent and nasal voice, Fran Drescher serves as an inspiration to many cancer patients as she successfully fought off the disease after suffering from uterine cancer. She is also an outspoken LGBT rights activist and healthcare advocate.
Jennifer Coolidge is an American actress. She is known for playing Jeanine Stifler in the sex comedy film series American Pie. Also known for her charity work, Coolidge has had a major impact working with organizations that support animal rights and AIDS assistance. Thanks to her performance in Legally Blonde, her voice has been the subject of a famous impression.
Cloris Leachman is an actress and comedian. One of the most decorated American actresses of all time, Cloris Leachman has won several prestigious awards in an illustrious career spanning more than seven decades; she is the most awarded actress in the history of Emmy Awards, along with Julia Louis-Dreyfus. She has also received an Oscar and a Golden Globe Award.
Rue McClanahan was an actress and comedian. Apart from being an actress, McClanahan was also an animal welfare advocate and one of the first celebrity patrons of the popular animal rights organization, PETA. She also supported nonprofit organizations, such as Alley Cat Allies. A woman ahead of her time, Rue McClanahan was a supporter of same-sex marriage and gay rights.
24 Betty White
Betty White, American actress and comedian, is considered as the pioneer of television and has had the longest television career of any entertainer, straddling more than 80 years. She’s known for her award-winning performances in shows like The Mary Tyler Moore Show, The Golden Girls and Hot in Cleveland.
An actress and comedian, Julia Louis-Dreyfus has won more Screen Actors Guild Awards and more Emmy Awards than any other artist in American television history. In 2016, she was named in Time magazine's 100 most influential people in the world list. In 2018, she was presented with America's highest comedy honor - The Mark Twain Prize for American Humor.
27 Leslie Jones
28 Gilda Radner
30 Nora Lum
31 Amy Schumer
American actor and stand-up comedian Amy Schumer is best known for the comedy series Inside Amy Schumer, which ran from 2013 to 2016. She was the creator and co-writer of the television show and also starred in it. She has also acted in films and has worked on the Broadway. She is known to address various social issues through comedy.
Queen Latifah is an American musician and actress whose song U.N.I.T.Y. played a major role in raising awareness about women's rights worldwide. Dubbed Queen of Jazz-Rap, Latifah has influenced several soul, R&B, and hip-hop artists like Remy Ma, Lil' Kim, Ivy Queen, Missy Elliott, Lauryn Hill, and Eve among other artists. As an actress, Latifah has won several prestigious awards.
35 Wanda Sykes
Wanda Sykes is an American actress, writer, and comedian. In 2004, Sykes was named in Entertainment Weekly magazine's list of 25 funniest people in America. Also known for her role as an activist, Sykes has been emceeing fundraisers and hosting events to tackle issues concerning same-sex marriages. She is also an ardent supporter of the Ruth Ellis Center.
37 Aubrey Plaza
Aubrey Plaza is an American actress, writer, producer, and comedian. She is best known for her portrayal of April Ludgate in the sitcom Parks and Recreation for which she earned a couple of nominations at the ALMA Award. Plaza is also known for playing Allison in the 2020 film Black Bear which earned her the Imagen Award for Best Actress.
39 Amy Sedaris
40 Joan Rivers
Famous for her controversial comedic persona, Joan Rivers was a television host and comedian. She broke stereotypes by hosting a late-night television talk show titled The Late Show with Joan Rivers, becoming the first woman to do so. Also an author, Rivers wrote 12 best-selling books. In 2017, she was posthumously inducted into the Television Academy Hall of Fame.
41 Teri Garr
Teri Garr is best known for her Academy Award-nominated role of Sandra Lester in Tootsie. Fans also loved her in Mr. Mom, One from the Heart, and After Hours. After revealing her long struggle with multiple sclerosis, she began raising awareness about the condition and retired from acting.
43 Nasim Pedrad
44 Bonnie Hunt
45 Maya Rudolph
A multi-talented personality, Maya Rudolph is known for her acting, singing, and comedic skills. Apart from playing supporting roles in popular films, such as 50 First Dates and Grown Ups, Maya played a crucial role in Saturday Night Live from 2000 to 2007, during which she impersonated personalities like Kamala Harris, for which she won the Primetime Emmy Award.
Spanish-American actress, singer, comedian, and flamenco-guitarist Charo, whose birth year remains a subject of dispute for several years, is known for her seductive deep voice with Spanish accent, unrestrained and exuberant manner, and the catch-phrase cuchi-cuchi. She has released albums like Guitar Passion, featured in films like The Concorde...Airport '79 and guest starred in TV series like The Love Boat.