54 Years Old Females

American actress, Melissa McCarthy, became famous when she starred in the television series, Gilmore Girls, which ran from 2000 to 2007. The sitcom, Mike & Molly, which ran from 2010 to 2016, further brought her accolades. She has also been part of films like This is 40, Identity Thief, The Heat, The Boss, Bridesmaids, Tammy, Spy and Can You Ever Forgive Me.

From being a lanky girl who was made fun of in school to becoming Hollywood’s A-list star, actress Uma Thurman has had quite a journey. She worked in various movies before landing on the film that earned her international appreciation, Quentin Tarantino's Pulp Fiction. Later, Tarantino's two Kill Bill movies and Mira Nair’s miniseries Hysterical Blindness further boosted her stardom.

Queen Latifah is an American musician and actress whose song U.N.I.T.Y. played a major role in raising awareness about women's rights worldwide. Dubbed Queen of Jazz-Rap, Latifah has influenced several soul, R&B, and hip-hop artists like Remy Ma, Lil' Kim, Ivy Queen, Missy Elliott, Lauryn Hill, and Eve among other artists. As an actress, Latifah has won several prestigious awards.

One of the most popular and decorated British-American actresses, Rachel Weisz is the recipient of many awards, such as the Academy Award. One of the most beautiful actresses, she has been featured on several magazine covers. In 2010, Rachel Weisz was named the global ambassador for L'Oréal. She has also served as fashion designer Narciso Rodriguez's muse.

Julie Bowen is an American actress whose performance in the television series Modern Family earned her six successive Primetime Emmy Award nominations, out of which she won twice. But what's really impressive and inspirational about this Marylander is that she achieved all this wearing a pacemaker in her chest all the way through—a real-life Iron Woman!

Leah Remini is best known as Carrie Heffernan from The King of Queens and Vanessa from Kevin Can Wait. She also appeared in Dancing with the Stars. She was raised a Scientologist, but turned against the faith later, releasing an explanatory memoir and an Emmy-winning documentary series on the same.

American actress Heather Graham gained recognition with her performance in the movie Drugstore Cowboy and Boogie Nights. She further appeared in movies like Lost in Space, Austin Powers: The Spy Who Shagged Me and The Hangover. Her television credits include Law & Order True Crime and Bliss. The beautiful actress also backs numerous charitable causes, especially those related to children.

Octavia Spencer is an American actress, producer, and author. Widely regarded as one of the best actresses of her generation, Spencer has received several prestigious awards, such as a Golden Globe Award, Academy Award, and Screen Actors Guild Awards. Octavia Spencer is the first black actress to have received two successive nominations at the Oscars.

American actress Ellen Pompeo attained fame when she acted in the 2002 film Moonlight. But she gained worldwide recognition for the portrayal of Dr Meredith Grey in the critically acclaimed and successful television series Grey’s Anatomy. She has also acted in films like Old School, Catch Me If You Can, In the Weeds, Art Heist, Daredevil and Life of the Party.

Aisha Tyler is credited with co-founding an all-female a cappella group called Dartmouth Rockapellas, which aimed at spreading social awareness through music. She later became a prominent actress, playing important roles in popular TV series like Criminal Minds and CSI: Crime Scene Investigation. Aisha Tyler is also an ardent advocate of the Black Lives Matter movement and LGBTQ rights.

Giada De Laurentiis is an Italian-American chef, restaurateur, television personality, and writer. She won the Gracie Award under the Best Television Host category for hosting Giada at Home. The founder of a catering business called GDL Foods, Giada De Laurentiis has been an influential figure in the American culinary business over the last few years.

A former model as well as timepiece and jewellery designer, Melania Trump is the wife of 45th US President Donald Trump and the current First Lady of the United States of America. The Slovenian-American is only the second foreign born and the first naturalized citizen to hold the title.

Broadcast journalist and television talk show host Tamron Hall is best known for her eponymous award-winning syndicated daytime talk show. She has previously worked for NBC News and MSNBC. An alumnus of Temple University, she is a member of the National Association of Black Journalists. She is actively involved in anti-domestic violence campaigns.

Queen Rania of Jordan is the current queen consort of Jordan. Since her marriage to Abdullah II of Jordan, Rania has focused on improving education and health in Jordan. In 2005, Queen Rania joined hands with the Ministry of Education to launch the Queen Rania Award for Excellence in Education, an annual teachers’ award.

Kristy Swanson is an American actress best known for playing Buffy Summers in the comedy horror film Buffy the Vampire Slayer. Also known for her good looks, Kristy Swanson turned heads when she posed nude in a cover-featured pictorial for Playboy magazine in 2002.

Nicole Ari Parker is best known for her role as Becky Barnett in the movie Boogie Nights. Fans also loved her as Teri Joseph in Soul Food and as Giselle Barker in the soap Empire. She also plays Samantha Miller in Chicago P.D. Nicole is an active Democrat.

Shonda Rhimes is a screenwriter, author, and television producer. She is credited with creating, writing, and executive producing one of the most popular American medical drama TV series ever, Grey's Anatomy. She is also credited with creating series like Private Practice and Scandal. In 2007, she was named in Time magazine's list of 100 People Who Help Shape the World.

Amy Jo Johnson is an American-Canadian filmmaker, actress, singer, and songwriter. Over the years, Johnson has been honored at several important film festivals including Long Island Film Festival and Toronto International Film Festival. A multi-talented personality, Amy Jo Johnson has also directed a couple of films like Tammy's Always Dying and The Space Between.

Actress, model, dancer, and fashion designer Sheri Moon Zombie originally aspired to a voice-over artist but fate had other plans in store for her. A chance meeting with her future husband, musician Rob Zombie, motivated her to become a dancer. She started acting soon after and has appeared in many films and TV shows. She is a vegan.

Essie Davis is an Australian singer and actress best known for playing Phryne Fisher in the drama television series, Miss Fisher's Murder Mysteries. Over the years, Davis has enjoyed considerable success in the Australian entertainment industry. She has received several prestigious awards, such as the Australian Film Institute Award and AACTA Award.

Gabriela Sabatini is an Argentine former professional tennis player. One of the leading female tennis players in the 1980s and 1990s, she amassed 41 titles, including the WTA Finals in 1988 and the 1990 US Open. She was inducted into the International Tennis Hall of Fame in 2006. Also a businesswoman, she runs a line of fragrances.

Tamara Taylor is a Canadian actress best known for her portrayal of Dr. Camille Saroyan in the popular crime procedural comedy-drama TV series, Bones. Taylor dropped out of high school in order to pursue modeling and travel around the world. Her mother's decision to support her daughter's choice of career proved to be fruitful as Taylor became a successful actress.

Paula Malcomson is a Northern Irish actress best known for playing Abby Donovan in the American crime drama TV series, Ray Donovan. Despite being a Northern Irish, Malcomson has worked in many American TV series and films. She portrayed the role of Mrs. Everdeen in the Hunger Games film series and has appeared in popular American TV series like ER.

Michelle Malkin is an American blogger, author, political commentator, and businesswoman. Her weekly syndicated column gets featured in several websites and newspapers. Apart from writing four books and contributing to TV channels, such as Fox News, Michelle Malkin is also credited with founding the conservative websites Hot Air and Twitchy.

Laurie Holden is an American-Canadian model, actress, and producer. She is best known for her portrayal of Andrea in the popular horror television series The Walking Dead, for which she received the 2012 Satellite Award and 2013 Saturn Award. Also known for her human rights activism and charity work, Laurie Holden works closely with organizations that campaign against human trafficking.