Anne of Cleves was the Queen of England for 6 months in 1540, as the fourth wife of King Henry VIII. Their unconsummated marriage deprived led to the annulment of the marriage, following which she received a settlement and came to be known as the King's Beloved Sister.
Alexandra Feodorovna, wife of Emperor Nicholas II, was the last Russian tsarina and reigned from 1894 to 1917. She suffered from hemophilia. Alexandra and her entire family were murdered by the Bolshevik revolutionaries. In 2000, the Russian Orthodox Church canonized her as Saint Alexandra the Passion Bearer.
Maria Alexandrovna of Hesse was the daughter of Prince Hereditary Ludwig of Hesse and Princess Wilhelmine of Baden. She was the first wife of Russian Emperor Alexander II. She was a co-founder of the Russian Red Cross and established Russia's first all-female schools. She also helped her husband end serfdom in Russia. She suffered from tuberculosis and died in 1880.
Alexandra Feodorovna Romanova was the daughter of Frederick William III, King of Prussia, and Duchess Louise of Mecklenburg-Strelitz. She had a difficult childhood and lost her mother when she was just 12. She married Nicholas I, who later reigned as Emperor of Russia. The couple had a happy marriage that lasted till Nicholas’ death in 1855.
The wife of King George II, Caroline of Ansbach served as the queen consort of Great Britain and Ireland from 1727 until her death in 1737. She also became the electress consort of Hanover upon George II's accession in 1727. Caroline is credited with bolstering the House of Hanover's place during a difficult period of political instability in Britain.
Elizabeth, the daughter of Hungarian king Andrew II, was married at 14 but lost her husband to a plague in Italy at 20. She then joined the Third Order of St. Francis and opened a hospital for the poor. She is revered as the patron saint of the homeless.